Paul Christou

Categoría: Professor Investigador (ICREA)

Área de conocimiento: Biotecnologia

Dirección: ETSEA, Edifici Principal A

Teléfono: +34 973 702831

E-mail: paul.christou@udl.cat

Personal Website: https://www.icrea.cat/Web/ScientificStaff/paul-christou-319

· Llicenciat en Ciències, Universitad de Londres, Chelsea College, UK, 1977
· Doctorat, Universitat de Londres, University College, UK, 1980

· 2004-actualitad, Investigador ICREA, Universitat de Lleida
· 2001-2004, Profesor, Fraunhofer Institute of Molecular Biotechnology and Applied Ecology, Schmallenberg, Aachen, Alemania
· 1998 – 1994, Profesor i Responsable de l'Unitad de Biotecnología, John Innes Centre, UK

· Biotecnologia aplicada a la obtención de cereales resistentes al estrés abiótico como sequía y salinidad.

Capell T, Twyman RM, Armario-Najera V, Ma JKC, Schillberg S, Christou P (2020) Potential applications of plant biotechnology against SARSCoV-2. Trends in Plant Science, https://doi.org/10.1016/j.tplants.2020.04.009.

Moreno JA, Díaz-Gómez J, Fuentes-Font L, Angulo E, Gosálvez LF, Sandmann G, Portero-Otin M, Capell T, Zhu C, Christou P, Nogareda C (2020)  Poultry diets containing (keto)carotenoid-enriched maize improve egg yolk color and maintain quality   Animal Feed Science and Technology   206:114334-114344

Jin X, Baysal C, Gao L, Medina V, Drapal M, Ni X, Sheng Y, Shi L, Capell T, Fraser PD, Christou P, Zhu C. (2019) The subcellular localization of two isopentenyl diphosphate isomerases in rice suggests a role for the endoplasmic reticulum in isoprenoid biosynthesis"  Plant Cell Reports  Nov 2. doi: 10.1007/s00299-019-02479-x.

Banakar R, Fernandez AA, Zhu C, Abadia J, Capell T, Christou P (2019) The ratio of phytosiderophores nicotianamine to deoxymugenic acid controls metal homeostasis in rice Planta 250:1339-1354    doi: 10.1007/s00425-019-03230-2

Mir-Artigues P, Twyman RM, Alvarez D, Cerda-Bennasser P, Balcells M, Christou P, Capell T (2019) A simplified techno-economic analysis of molecular pharming  Biotechnology and Bioingenieering 116:2526-2539   doi: 10.1002/bit.27093.

Diaz Benito P, Banakar R, Rodriguez-Menendez S, Capell T, Pereiro R, Christou P, Abadía J, Fernández B, Álvarez-Fernández A (2018) Iron and zinc in the embryo and endosperm of rice (Oryza sativa L.) seeds in contrasting 2’-deoxymugineic acid/nicotianamine scenarios  Frontiers in Plant Science doi: 10.3389/fpls.2018.01190

Zanga D, Sanahuja G, Eizaguirre M, Albajes R, Christou P, Capell T, Fraser P, Gerrisch C, López C (2018) Carotenoids moderate the effectiveness of a Bt gene against the European corn borer, Ostrinia nubilalis   PlosOne 13(7):e0199317. doi: 10.1371/journal.pone.0199317. eCollection 2018.

Vamvaka E, Farré G, Molinos-Albert  LM, Evans A, Canela-Xandri A, Twyman RM, Carrillo J, ordoñez RA, Shattock R, O’Keefe BR, Clotet B, Blanco J, Khush GS, Christou P, Capell T (2018) Unexpected synergistic HIV neutralization by a trile microbicide produced in rice endosperm. Proc Natl Acad Sci of USA 115: E7854-E7862

Pérez L, E Soto, G. Villorbina, L Bassie, V Medina, P Muñoz, T Capell, C Zhu, P Christou, G Farré (2018) CRISPR/Cas9-induced monoallelic mutations in the cytosolic AGPase large subunit gene APL2 induce the ectopic expression of APL2 and the corresponding small subunit gene APS2b in rice leaves Transgenic Research 27: 423-439

Berman U, Zorrilla-Lopez U, Sandmann G, Capell T, Christou P, Zhu C (2017) The silencing of carotenoid B-hydroxylases by RNA interference in different maize genetic backgrounds increases the b-carotene content of the endosperm. International Journal of Molecular Sciences 18:2515

Díaz-GómeZ J, J.A. Moreno, E. Angulo, G. Sandmann, C. Zhu, AJ Ramos, T. Capell, P. Christou, Nogareda C (2017) High-carotenoid biofortified maize is an alternative to color additives in poultry feed Journal: Animal Feed Science and Technology     231:38-46

Banakar R, Alvarez-Fernandez A, Díaz-Benito P, Abadia J, Capell T, and Christou P (2017) Phytosiderophores determine thresholds for iron and zinc accumulation in biofortified rice endosperm while inhibiting the accumulation of cadmium   J Exp Bot  68:4983-4995

Zhu C; Farre G; Zanga D; Lloveras J; Michelena A; Ferrio JP; Voltas J; Slafer GA; Savin R; Albajes R; Eizaguirre M; Lopez C; Cantero-Martínez C; Díaz-Gómez J; Nogareda C; Moreno JA; Angulo E; Estany J; Pena RN; Tor M; Portero-Otin M; Eritja N; Arjó G; Serrano JCE; Matias-Guiu X; Twyman RM; Sandmann G; Capell T; Christou P (2018) High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition   Phytochemistry Reviews  17: 195-209

Berman, J; Zorrilla, U; Medina, V; Farré, G; Sandmann, G; Capell, T; Christou, P; Zhu, C (2017) The Arabidopsis ORANGE (AtOR) gene promotes carotenoid accumulation in transgenic corn hybrids derived from parental lines with limited carotenoid pools   Plant Cell Reports  36:933-945

Diaz-Gomez J, Twyman RM, Zhu C, Farre G, Serrano JCE, Capell T, Christou P (2017) Biofortification of crops with nutrients: factors affecting utilization and storage. Current Opinion in Biotechnology   44: 115-123

Zanga D, Capell T, Slafer GA, Christou P, Savin R (2016) A carotenogenic mini-pathway introduced into white corn does not affect development or agronomic performance Scientific Reports 6: 38288

Moreno JA, Diaz-Gomez J, Nogareda C, Angulo E, Sandmann G, Portero-Otin M, Serrano JCE, Twyman RM, Capell T, Zhu C, Christou P (2016) The distribution of carotenoides in hems fed on biofortified maize is influenced by feed composition, absortion, resource allocation and storage  Scientific Reports 6:35346

Bortesi, L; Zhu, C; Zischewski, J; Perez, L; Bassié, L; Nadi, R; Forni, G; Lade, S; Soto, E; Jin, X; Medina, V; Villorbina, G; Muñoz, P; Farré, G; Fischer, R; Twyman, R; Capell, T; Christou, P; Schillberg, S (2016) Patterns of CRISPR/Cas9 activity in plants, animals and microbes. Plant Biotechnology Journal   14:2203-2216

Banakar; Alvarez Fernández, Á; Abadia, J; Capell, T; Christou, P (2016)  The expression of heterologous Fe (III) phytosiderophore transporter HvYS1 in rice increases Fe uptake, translocation and seed loading and excludes heavy metals by selective Fe transport. Plant Biotechnol J 15: 423-432

Zhu C, Bortesi L, Baysal C, Twyman RM, Fischer R, Capell T, Schillberg S, Christou P (2017) Characteristics of genome editing mutations in cereal crops. Trends in Plant Science  22: 38-52

Bai C., Berman J., Farre G., Capell T., Sandmann G., Christou P., Zhu C (2017) Reconstruction of the astaxanthin biosynthesis pathway in rice endosperm reveals a metabolic bottleneck at the level of endogenous β-carotene hydroxylase activity. Transgenic Research 26:13-23

Berman J, Sheng Y, Gómez Gómez L, Veiga T, Ni X, Farre G, Capell T, Guitian J, Guitian P, Sandmann G, Christou P Zhu C, (2016) Red anthocyanins and yellow carotenoids form the color of orange-flower gentian (Gentiana lutea L. var. aurantiaca) PLoS ONE doi:10.1371/journal.pone.0162410.

Breitenbach J, Nogueira M Farre G Zhu C Capell T Christou P Fleck G Fockem U Fraser PD Sandmann G (2016) Engineered maize as a source of astaxanthin: processing and application as fish feed. Transgenic Research 25: 785-739

Comas, J; Benfeitas, R; Vilaprinyo, E; Sorribas, A; Solsona, F; Farré, G; Berman J, Zorrilla U, Capell, T; Sandmann, G; Zhu, C; Christou, P; Alves, R (2016) Identification of line-specific strategies for improving carotenoid production in synthetic maize through data-driven mathematical modelling The Plant Journal  87: 455-471.

Vamvaka, E; Arcalis E, Ramessar, K; Evans, A; O'Keefe, B; Shattock, R; Piles, V; Stoger E, Christou, P; Capell, T (2016) Cyanovirin-N produced in rice endosperm offers effective pre-exposure prophylaxis against HIV-1BaL infection in vitro    Plant Cell Reports   35: 1309-1319

Farré G, Perez-Fons L, Decourcelle M, Breitenbach J, Hem S, Zhu C, T Capell, Christou P, Fraser PD, Sandmann G (2016) Metabolic engineering of astaxanthin biosynthesis in maize endosperm and characterization of a prototype high oil hybrid  Trangenic Research   25:477-489

Vamvaka, E; Arcalis E, Ramessar, K; Evans, A; O'Keefe, B; Shattock, R; Piles, V; Stoger E, Christou, P; Capell, T (2016) Rice endosperm is cost effective for the production of recombinant griffithsin with potent activity against HIV . Plant Biotechnology Journal  14: 1427-1437

S Ahrazem O, Rubio-Moraga A, Berman J, Capell T, Christou P, Zhu C, Gómez-Gómez L (2016) The carotenoid cleavage dioxygenase CCD2 catalysing the synthesis of crocetin in spring crocuses and saffron is a plastidial enzyme. New Phytologist  209: 650-663

Zanga, D; Capell, T; Zhu, C; Christou, P; Thangaraj, H (2016) Freedom-to-operate analysis of a transgenic multivitamin corn variety Plant Biotechnol Journal. 14: 1225-1240

Chang; S J Berman; Y Sheng; Y Wang; T Capell; L Shi; X Ni; G Sandmann; P Christou; C Zhu (2015) Cloning and functional characterization of the maize (Zea mays L.) carotenoid epsilon hydroxylase gene PLoS ONE  10(6):e0128758. doi: 10.1371/journal.pone.0128758.

Bai, C T.Capell, J Berman, V Medina, G.Sandmann, P.Christou, C. Zhu (2016) Bottlenecks in carotenoid biosynthesis and accumulation in rice endosperm are influenced by the precursor–product balance. Plant Biotechnology Journal  14:195-205

Nogareda, C; Moreno, JA; Angulo, E; Sandmann, G; Portero, M; Capell, T; Zhu, C; Christou, P (2016) Carotenoid-enriched transgenic corn delivers bioavailable carotenoids to poultry and protects them against coccidiosis. Plant Biotechnology Journal  14: 160-168

Vamvaka E, Twyman RM, Murad A, Melnik S, Teh A, Arcalis E, Altmann F, Stoger E, Rech E, Ma J, Christou P, Capell T.(2016) A recombinant HIV-neutralizing antibody produced in rice endosperm accumulates predominantly as an aglycosylated derivative with enhanced neutralizing activity. Plant Biotechnology Journal  14: 97-108

Per mes informació (Consultes GREC)